my-cart-icon svg-arrow-next svg-arrow-prev

Methyl 12 Plus

Activated vitamin B formula to support healthy metabolic function and energy production.


Activated Methyl B12  vitamin B formula to support healthy metabolic function and energy production.


Dr. Peter D'Adamo designed our advanced Methyl 12 Plus formula to promote and maintain natural energy levels, optimize the body's methylation capabilities and help to regulate sleep patterns.


Dr. Peter D'Adamo:

"Many popular formulas continue to use outdated forms of vitamin B12 and folic acid, either because they have not kept up with the science literature, or they've simply opted to produce the cheapest possible product and sell it by stressing its low cost."  


Methyl 12 Plus blends together two biologically 'active' forms of vitamins B12 which contains both (methylcobalamin and adenosylcobalamin) and the biologically active form of vitamin B9 (folate) to maximize absorption, utilization and support a healthy nervous system and aid in blood cell production.


Dr. Peter D'Adamo:

"Studies suggest that 60-70% of the general population have at least one gene variant that makes it difficult for them to process the cheaper form of vitamin B12 (cyanocobalamin) seen in many supplements."  


Why is proper methylation important?


Methylation is a chemical modification of DNA and other molecules that may be retained as a type of 'memory' as cells divide to make more cells. When found in DNA, methylation can alter gene expression. In this process, chemical tags called methyl groups attach to a particular location within DNA where they turn a gene on or off, thereby regulating the production of proteins that the gene encodes.


How methylation impacts the body. Nutrient deficiencies, environmental exposures, and other aspects of a modern lifestyle can cause inefficient methylation.



Methylation significantly impacts many biochemical reactions in the body and plays a beneficial role in:

  • The health of our heart and arteries
  • The production of energy inside our cells
  • Our metabolism of fats and lipids
  • The healthy function of our nervous system
  • DNA production and maintenance

Methyl 12 Plus does not contain the synthetic form of B9, often referred to as folic acid. Instead, Dr. D'Adamo used the nature-identical and fully active Vitamin B9 (folate).


Dr. Peter D'Adamo:

"Leave the folic acid in the breakfast cereal aisle, where it belongs. Folate as calcium folate is what the body actually requires; and although folate can be made from folic acid, many people cannot do a proper job of it."   


Methyl 12 Plus is one of our most popular formulas, with highly rated consumer reviews that attest to its clear clinical effectiveness. Methyl 12 Plus is 100% vegetarian and is suitable for all blood types. It is produced in the USA and is a GMP (Good Manufacturing Practices) quality assured and certified product as outlined by the Natural Products Association, with an "A" compliance rating. This 100% vegetarian product contains no sugar, salt, gluten, wheat, yeast, corn, soy, eggs or dairy, no preservatives, color or flavors, and no artificial ingredients.

Size 60 vegetarian capsules
Suggested Use One (1) capsule per day, or as directed by your physician, as a dietary supplement
Usable by all types Yes

60 vegetarian capsules
Suggested Use: 1 capsule a day

Is this Product Vegetarian? Yes

Practitioner Technical Information

Must login as a practitioner to have access.

Methyl 12 Plus TRM

Returns Policy

You may return most new, unopened items within 30 days of delivery for a full refund. We'll also pay the return shipping costs if the return is a result of our error (you received an incorrect or defective item, etc.).

You should expect to receive your refund within four weeks of giving your package to the return shipper, however, in many cases you will receive a refund more quickly. This time period includes the transit time for us to receive your return from the shipper (5 to 10 business days), the time it takes us to process your return once we receive it (3 to 5 business days), and the time it takes your bank to process our refund request (5 to 10 business days).

If you need to return an item, simply login to your account, view the order using the "Complete Orders" link under the My Account menu and click the Return Item(s) button. We'll notify you via e-mail of your refund once we've received and processed the returned item.


We can ship to virtually any address in the world. Note that there are restrictions on some products, and some products cannot be shipped to international destinations.

When you place an order, we will estimate shipping and delivery dates for you based on the availability of your items and the shipping options you choose. Depending on the shipping provider you choose, shipping date estimates may appear on the shipping quotes page.

Please also note that the shipping rates for many items we sell are weight-based. The weight of any such item can be found on its detail page. To reflect the policies of the shipping companies we use, all weights will be rounded up to the next full pound.

Related Products